OTSC® System: 84% Risk reduction in colonic diverticular hemorrhage

OTSC® reduces early recurrent bleeding risk by 84% (OR 0.16; p = 0.017) versus endoscopic band ligation in propensity-matched analysis of colonic diverticular bleeding

Key findings

• Significantly lower 30-day recurrent bleeding rate with OTSC® (2.9%; 2/68) vs. endoscopic band ligation (EBL) (16.2%; 11/68) in matched cohort (OR 0.16; 95% CI 0.02 – 0.77; p = 0.017)
• 100% initial hemostasis rate achieved with both OTSC® and EBL in matched cohort (68/68 each; no significant difference)
• Significantly shorter median hospital stay after OTSC® treatment (6 days) vs. EBL (7 days) in the matched cohort (p = 0.026)
• No significant differences in requirements for interventional radiology, surgery, red blood cell transfusion, or adverse events between the groups

Study details

• Retrospective cohort study with propensity score matching at Japanese medical center (08/2014 – 12/2023)
• 303 cases (247 patients) with colonic diverticular bleeding; 68 matched cases per group
• Aim: Comparison of effectiveness between EBL and OTSC® using propensity score matching to address potential confounders
• Primary endpoints: Initial hemostasis and 30-day recurrent bleeding
• Secondary endpoints: Requirements for interventional radiology, surgery, red blood cell transfusion, hospital stay, and adverse events

Ohashi Y, Sugiyama H, Ideta T, Hino T, Mizutani S, Adachi H, Oshima Y, Shimizu M. Comparison of endoscopic band ligation versus over-the-scope clip for colonic diverticular bleeding: a propensity score-matched cohort analysis. Gastrointest Endosc. Published online 2025, August 18. doi:10.1016/j.gie.2025.08.013.

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