New multicenter study: FTRD® again delivers high success rates in colorectal EFTR

FTRD® achieves high technical success and R0 resection rates in EFTR of complex colorectal lesions and early colorectal cancers, with a manageable safety profile

Key findings

• 89% technical success rate (151/170 procedures)
• 79% R0 resection rate (130/164 evaluable cases)
• Adenocarcinoma confirmed on histopathology in 23% (39/170) of lesions
• Recurrence rate of 7.4% (11/148) over a median follow-up of 5 months
• Adverse events (AEs) occurred in a minority of cases: early in 4.1% (7/170) of cases including snare malfunction (n = 2), bleeding (n = 3), and perforation (n = 2); delayed: 12.9% (22/170) of cases, most commonly bleeding (n = 11)
• Appendicitis occurred in 17% (7/41) of appendiceal cases
• AEs were significantly associated with female sex (64% vs. 40%, p = 0.03) and appendiceal orifice lesions (46% vs. 21%, p = 0.02)

Study details

• Multicenter, retrospective cohort study across 13 centers in Australia and New Zealand (January 2018–July 2025)
• 170 colorectal EFTR procedures with FTRD® (mean patient age: 67 years; 57% male; comorbidities: 65%)
• Aim: Evaluation of technical success, histological outcomes, recurrence rates, and safety of colorectal EFTR with FTRD®, and identification of patient- and lesion-related predictors of AEs
• Indications: Resection of scars after previously incomplete resection of cancer (12%), suspected amyloidosis (diagnostic, 2%), appendiceal orifice polyp (23%), diverticular-associated polyp (3%), recurrence at prior polypectomy site (21%), non-lifting lesion (36%), subepithelial lesion (2%)
• Mean procedure time: 51 min (SD 28.5)
• Mean lesion size: 19 mm (SD 7.3)

McGarrigle V, Shimamura Y, Zorron Cheng Tao Pu L, Efthymiou M, Vaughan R, Schauer C, Sekra A, Horsfall E, Simpson A, Singh R, Wan N, Bassan M, Harb M, Terkasher B, Weilert F, Gupta S, Yee KC, Patel R, Hassan I, Theron B, Chandran S. Clinical Outcomes of Colorectal Endoscopic Full-Thickness Resection Using the Full-Thickness Resection Device: A Multicenter Study. DEN Open. 2026;7(1):e70365. doi:10.1002/deo2.70365 (Open Access).

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