BARS® shows >10% TBWL via endoscopic GJA reduction in RYGB

BARS® shows promise as an effective, minimally invasive intervention for GJA reduction in patients with weight regain after RYGB, yielding >10% TBWL at 6 months

Key findings

• Mean total body weight loss (TBWL) after BARS®:
  o 10.2% at 1 month
  o 12.6% at 3 months
  o 11.45% at 6 months
• Pre-procedure GJA diameter and anti-obesity medication (AOM) use were not associated with weight loss outcomes

Study details

• Retrospective observational study in the USA
• 17 patients undergoing endoscopic anastomosis lumen reduction with BARS®
  (mean age: 50.7 years; 79% female; mean BMI: 39.4 kg/m²)
• Aim: Evaluation of early weight-loss outcomes and predictors of response associated with reduced anastomotic diameters (response was defined as ≥8% TBWL)
• Investigated predictors of response:
  Pre-procedure GJA diameter, pre-procedure pouch length and AOM use
• Indication: Weight regain after Roux-en-Y gastric bypass (RYGB)
  (mean 13.7 years post-surgery; 71% on AOM)

Azam A, Khurana A, Stanek E, Flora B, Whitson L, Patel R, Chatterjee A, Firkins S, Simons-Linares R. Early Weight-Loss Outcomes and Predictors of Response Following Transoral Outlet Reduction (TORe) using a Novel Over-The-Scope Clip Device. Presentation at Digestive Disease Week (DDW) 2026 (2-5 May), Chicago, Illinois, USA.

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