HemoPill® acute shows high potential as a predictive tool to avoid emergency endoscopies

HemoPill® acute showed a high negative predictive value for active bleedings and enabled the avoidance of emergency endoscopies

Key findings

• Emergency endoscopies were avoided in 95.1% (37/41) of intended-to-diagnose cases and in 94.9% (37/39) of per-protocol cases
• Study showed a high sensitivity of 100% (9/9) and a negative predictive value for active UGIB of 100% (39/39 patients)
• HemoPill® acute was used in 73 cases of suspected UGI bleeding
• capsule showed no signs of bleeding in 56.2% (n=41) of cases and signs of bleeding in 43.8% (n=32)
• Technical success was 100%)

Study details

• 37 patients in the capsule negative group underwent an endoscopy within 48-96 hours. n=0 patients showed active bleeding signs
• Mean Glasgow-Blatchford Score for both groups was 10
• An EGD was performed within 12 hours for the capsule positive group and between 48 to 96h for the capsule negative group
• In the capsule negative group, 1 patient refused EGD, 1 suffered ischaemic strike and 2 underwent emergency endoscopies due to persistent hypertension (no active bleeding was revealed)

Brand M, Vogt G, Weich A, Hann A, Kudlich T, Weber M, Wedi E, Kuellmer A, Schmidt A, Brunk T, Meining A. Use of a novel photometric capsule in suspected nonvariceal upper gastrointestinal bleeding a prospective multicenter study. UEG Week. October 12-15, Vienna.