Hybrid EMR-FTRD® shows promise for large colonic lesions with suspected cancer

International study demonstrates high technical success and favorable oncological outcomes for hybrid approach combining EMR and FTRD® in challenging colonic lesions

Key findings

• High technical success rate achieved with Hybrid-FTRD® technique in 86% (n=51/59) for large colonic lesions with suspected T1 cancer
• No locoregional cancer recurrence was observed during the median follow-up of 16 months
• R0 resection was achieved in 92% of sm1 lesions and 65% of sm2-3 lesions
• 3% adverse events requiring surgical intervention

Study details

• International, multicenter cohort study including data from the Dutch prospective FTRD® registry and three German centers
• 59 patients with large lateral spreading tumors (median size 25mm) with focal suspicion of T1 cancer
• Patients had a median age of 72 years, 53% were male
• Lesion locations: 68% in proximal colon, 32% in distal colon
• Pathological findings confirmed pT1 lesions in 61% of cases, with 53% classified as low-risk and 47% as high-risk

Albers SC, Wannhoff A, Zwager LW, Boonstra JJ, Fockens P, Houben MHMG, Ten Hove R, Küllmer A, Perk L, Schreuder RM, Schwartz MP, Schmidt A, Van der Spek B, Terhaar Sive Droste JS, Wientjes C, Dekker E, Bastiaansen BAJ. Hybrid endoscopic mucosal resection with endoscopic full thickness resection for large colonic lesions with focal suspicion of submucosal invasive cancer: an international, multicentre cohort study. ESGE Days 2025 (3-5 May), Barcelona, Spain.