HemoPill® acute helps to avoid unnecessary emergency endoscopy in patients with high GBS

HemoPill® acute shows high negative predictive value, highlighting its potential to identify patients that do not require an emergency endoscopy and thereby save personnel and financial resources

Key findings

• 100% sensitivity and negative predictive value of the HemoPill®
• 95.1% of emergency endoscopies were avoided in in group B (negative HemoPill® value and median Glasgow-Blatchford (GBS) of 11; n=37)
• No technical, capsule-related or bleeding-related complications occurred during the follow-up period of 30 days

Study details

• 73 patients with suspected NVUGIH (non-variceal upper gastrointestinal hemorrhage) at 4 German centers were stratified into two groups:
  • Group A with a positive HemoPill® result indicating bleeding underwent emergency endoscopy within 12 hours (n=32)
  • Group B with a negative result underwent elective endoscopy between 48-96 hours (n=41)
• Patients in both groups had a median GBS of 11
• The primary end point was the rate of avoided emergency endoscopies in group B

Brand M, Vogt G, Hann A, Weich A, Kudlich T, Lux T, Weber M, Wedi E, Kuellmer A, Schmidt A, Brunk T, Meining A. Pilot study on using a photometric capsule to stratify patients with suspected nonvariceal upper gastrointestinal bleeding into emergency versus elective endoscopy. Endoscopy. 2025 Sep 3. Epub ahead of print. DOI: 10.1055/a-2679-6906.