Complication Management

What can you do if a clip needs to be removed? In such cases, appropriate complication management is required.

Ovesco clips are biocompatible and can remain in the body permanently. In most cases, they detach on their own after healing is complete and are excreted naturally. However, there are situations in which targeted removal of the clip may be necessary. Ovesco takes a multifaceted approach that goes beyond mere application and also includes complication management with the remOVE System.

Indications

A major challenge in stent placement is the subsequent risk of migration. With the stentFIX System, stents can be fixed distally and proximally to significantly reduce this risk. A specially designed Ovesco clip is used to fix the stent to the tissue. For subsequent removal of the stent, the fixing clip can be systematically fragmented and removed with the remOVE System.

In rare cases, a clip may be accidentally placed in an unintended location. Removal is then necessary to avoid complications and ensure correct therapy. The remOVE System provides the necessary safety during clip placement, especially for beginners.

In rare cases, during certain endoscopic procedures, an instrument may be accidentally clipped to the tissue. The remOVE System offers a reliable and gentle way to remove the clip, solving the problem quickly and reliably.

In rare cases, clip placement can lead to complications such as lumen narrowing, which may require removal of the clip.

For diagnostic purposes or repeat endoscopic therapy, it may be necessary to make the clip site accessible for biopsy or re-resection.

An MRI scan is necessary near the clip, but the clip may cause artifacts in the imaging. To prevent this, the clip can be removed with the remOVE System, enabling high-quality diagnostic imaging without interference.

Even though Ovesco clips can remain in the patient's body without any problems, there are cases where patients want to have the clips removed. With the remOVE System, this request can be fulfilled quickly and easily.

Procedure

The remOVE System is the only system to easily remove clips from the gastrointestinal tract. It consists of various components, including the remOVE DC Impulse Generator, which generates a direct current impulse, the DC Cutter, which cuts the clip using direct current, and the SecureCap, which securely retrieves the clip fragments. For this purpose, the remOVE Grasper is used as a grasping instrument to secure the clip fragments in the SecureCap. The system also includes the remOVE Shield*, which protects the endoscope lens from flying sparks.

To remove the clip, the DC Cutter is inserted through the working channel and the clip is fragmented at two opposite points. The clip fragments are then mobilized into the SecureCap using the Grasper. This allows them to be retrieved while protecting the tissue at the same time.

*The remOVE Shield may not be available in all regions

Case examples

Clip removal to remove a fixed stent

With the help of the stentFIX System, metal stents can be fixed in place in such a way that the migration rate is significantly reduced. To remove the stents again, the clips of the stentFIX System are removed with the help of the remOVE System.

Clip removal after full-thickness resection

In this clinical video, an Ovesco clip is removed after a full-thickness resection with the FTRD® System for follow-up.

Clinical Background

Clinical evidence confirms the high effectiveness of the remOVE System for the endoscopic removal of Ovesco clips. In a multicenter post-market clinical follow-up analysis by Caputo et al. (2017), successful fragmentation of the clip was achieved in 97.3% of cases in 74 patients. Complete removal of all clip fragments was achieved in 85.1% of cases. Complications were rare (n=3), with minor bleeding occurring in 2.7% of patients and superficial mucosal tears in 1.4%. All complications could be treated endoscopically.

A systematic review by Ou et al. (2020) confirms the high technical success rate: the pooled success rate for fragmentation of Ovesco clips with the remOVE System was 97%, and for complete removal it was 89%. In the pooled analysis, minor complications occurred in 7% of cases. The authors emphasize that the remOVE System is the best-studied and most reliable method for clip removal.

This is also shown in a case report by Pham et al. (2016). Here, an initial attempt was made to remove a clip using argon plasma coagulation, which led to tissue damage, while subsequent removal with the remOVE System was successful without complications. Removing the clip with APC is therefore not a suitable alternative to the remOVE System.

A study by Bauder et al. (2016) investigated how long it takes to remove different types of clips with the remOVE System. Of a total of 42 attempts, 39 clips (92.9%) were successfully removed completely. Even clips with a thicker wall thickness, such as FTRD® clips, could be removed in a comparable time: The average time to remove a clip was 49 minutes for OTSC® clips and 54 minutes for FTRD® clips. Clips with strong ingrowth or overgrowth were more challenging and took longer to remove.

Further information

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